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Production ofthe actual fibril occursoutside the cell and involves enzymatic activity at the plasmamembrane to produce the collagen molecule, followed byassembly of the molecules into fibrils in the ECM underguidance by the cell (Fig Production ofthe actual fibril occursoutside the cell and involves enzymatic activity at the plasmamembrane to produce the collagen molecule, followed byassembly of the molecules into fibrils in the ECM underguidance by the cell (Fig. During the third day after fertiliza-tion, the morula, which has reached a 12- to 16-cell stage andis still surrounded by the zona pellucida, enters the uterinecavity During the third day after fertiliza-tion, the morula, which has reached a 12- to 16-cell stage andis still surrounded by the zona pellucida, enters the uterinecavity. Methods of meta-analysis:Correcting error and bias in research findings (2nd ed.). 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Multiple intraoperative tissue specimens should beobtained, and cultures should be optimized to yield P. This criticism is not new or unique to newer-generation neuromonitoringdevices. Moreover, physiological constraintsmay limit the in vivo impact of variability observed in vitro.For instance, high-affinity intrinsic clearance can result inessentially complete metabolism of all the chemical reach-ing the liver in the blood; under these conditions, variabilityin amount metabolized in vivo would be more a function ofvariability in liver blood flow than variability in metabolismin vitro. Diagnosis of periprosthetic joint infections in clinical practice.